CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Abstract Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity.Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells.The confidence of the cell-to-clone mapping can b

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Imaging features in calcinosis circumscripta, a rare type of subcutaneous calcification in localized scleroderma

Calcinosis cutis circumscripta is a rare condition in which abnormal deposition of calcium seen in the dermis and subcutaneous tissue, it is associated with localized scleroderma.A 30-year-old female presented with an area of extensive calcification biomat for sale involving the right gluteal region, lateral aspect of right thigh and a small area o

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